The algorithm to separate the cab from the amp is not perfect, therefore the result won't be "kosher" (wouldn't sound like this combination in real-life). That doesn't mean it can't sound great.
today i was testing a mbritts profile Helios that was sounding mehh but i changed the cab and omg glorius sound,i used a LRS ir
Guidorist said that he is not a fan of switching cabs but i think after some testing that switching can make some profiles sound awesome