What if I wanted to use SPDIF for dry signal and then L/R (XLR or 1/4), would this still work
Of course it would work even though I don't do it this way (my studio in Germany is built around the RME UFX+ and my studio in Kathmandu, Nepal has the RME UFX II). If you want to do it like you wrote, just make sure you go XLR female -> TRS from Main Outputs of Profiler to Line Inputs on the audio interface. This gives you a balanced connection.
... then maybe from ADI 2 L/R output to another L/R input on the interface (1/4), my microphone would connected to a preamp which then connects to the ADI-2 ...
I would not do that even though it would work, technically.
1. I don't see an advantage of running your mic preamp through the ADI-2's AD and DA stages just to end up with yet another AD stage in the audio innterface. In my opinion it's one redundant conversion. If you really want to use the ADI-2, at least stay in the digital domain and use AES/EBU to go from ADI-2 into the audio interface.
2. The converters in the RME UCX II are exceptionally good within their limits (up to 192kHz sample rate PCM). I highly doubt you'll do DSD music production or even 384kHz or 768kHz. To be honest, I think you'll be pleasantly surprised if you skip the ADI-2 and connect your mic preamp directly to a line input of the UCX II.