I recently did some profiling of my amp collection and I can honestly say when I A-B'd the Kemper profile from the original amps I could not reliably tell the difference. I recorded a section from both and on playback there's no discernible difference if the levels are matched.
I have a good studio with $10,000 monitors so I can trust what I'm hearing. I'm yet to try profiling without a speaker but I will in time. I'm not sure how useful that would be to me in the studio.
Anyway, just adding to the view that you ears should be the final judge.
Marcus