Yamaha DXR10 Settings

The input doesn't matter, set the volume accordingly. I tend to go not more than -3 dB.
Make sure you have switched to LINE.
I tend to use the monitor DSP setting or switched to off.
HPF is off.

I run 2 dxr12s, and I tend to leave all the EQ attenuating settings off when dialing in my sounds LOUD. That way I can really hear exactly what my core tone is going to sound like. After that is complete, depending on the venue, I may engage the high pass at 100hz option. I still generally do not use FOH or monitor mode, just everything off as stated. Between my Adam a7xs, then further dialing in on my dxr12s, I've had the most consistent and best tones live I've ever had in my life, really nothing else to say. I still generally listen out front by the board ( I'm wireless) as our personal soundguy is dialing us in, but so far, I have yet to make a tweak "on the fly" compared to what I dialed in at home or loud at practice ( usually just at home) our sound guy for me generally just applies a high pass at 100hz on me on the FOH mains, " maybe" a low pass around 12k ( generally never needed for the style of tones I use) and that's about it. I never use EQ tweaks from the output menu either, just not really needed for me. If the profile doesn't work at the core and I'm finding I have to add graphic EQ's etc i won't use it, so many profiles now available it's not needed for me personally, that is just me though. Hope that helps.

Every EQ setting an DSP switched off.
Line2 with set to approx. -3db.
connected via monitor out.

Why do you dial out the mids?

It will tend to sound lifeless when you dial out too many mids.
You should make a rig with an EQ tailored for your Acoustic instead.

What guitar (acoustic vs. electric), amps (clean vs. distorted), music are you playing?
I can't complain about having a thin sound with my DXR. Actually my band mates thought it is too thick....so I use the 100Hz filter on the DXR during rehearsal...that fixes it.

Here's another vote for the 100Hz high pass filter in the DXR10, I've always thought it sounded too boomy with that switch set to "off".

Interestingly after I decided to make that setting "permanent" I told the sound guy in the venue we always play to engage the 100Hz cut button in the mixer if he felt my KPA was sending too much bass but he said it wasn't.

And that's into a PA with a huge subwoofer.

Also worth noting is that since I had tweaked all my rigs with the 100Hz switch set to "On", it was to be expected that my rigs would be a bit bass-heavy. But they weren't. So what does that tell us? My guess is that the DXR10's response curve is closer to "flat" with the 100Hz switch engaged than with it set to off.

Odd.. with my DXR10 I haven't so much bass response (with KPA's equalizer on flat position) and I even tend to add some bass in some open venues.
I think it also depends on the kind of guitar, I use a Stratocaster with low height pickups

Quote from Deny

Here's another vote for the 100Hz high pass filter in the DXR10, I've always thought it sounded too boomy with that switch set to "off".

Interestingly after I decided to make that setting "permanent" I told the sound guy in the venue we always play to engage the 100Hz cut button in the mixer if he felt my KPA was sending too much bass but he said it wasn't.

And that's into a PA with a huge subwoofer.

Also worth noting is that since I had tweaked all my rigs with the 100Hz switch set to "On", it was to be expected that my rigs would be a bit bass-heavy. But they weren't. So what does that tell us? My guess is that the DXR10's response curve is closer to "flat" with the 100Hz switch engaged than with it set to off.

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I don't believe that switching on the lowcut below 100 Hz can make the DXR sound more flat.
Because by definition it alters the frequency response curve by cutting below 100 Hz.
This would be a paradox concerning the FRFR paradigm.

That doesn't mean that the switch isn't useful though.

Yeah. For an FRFR sound one also needs an FRFR installation and room