Hi,
As long as the ohm is compatible most power amp and speaker cab combination will work.
Just make sure to adjust the volume after how much w the speakers can handle.
My personal choice wouldn't be that Crown power amp because it's very heavy at 10,4 kg and today there are much lighter options available only weighing a few kg. Plenty of lighter models to choose from.
You need to decide what you prefer, or get both options.
kemper (kemper cabs bypassed) + power amp + guitar cab
kemper (kemper cabs on) + powered full range monitor
A previous post from me in this thread about the differences. Also search the forum for many more threads about what users prefer.
Want to buy a Kemper, but have question
Good luck. 
Yes, as long as all the sounds you want to use will sound great through that Mesa cabinet.
Thanks for the responses!! The reason I asked about the Crown amp is because I already have one that isn't being used. I was hoping not to have to new a new amp.
The Mesa cab is 240w at 8 Ohm Mono / 4 Ohm Stereo
The Crown amp is 200W - 8 ohm Stereo (per channel)/300W - 4 ohm Stereo (per channel)/600W - 8 ohm Bridge-Mono
How would you suggest to hook them up?
Sorry, I am quite noobish at technical jargon. 
All in all, I'd send the main outs stereo to FOH and use the Crown/Mesa in mono via monitor outout (Cabs off). You'll want to use the Crowne's bridged mono mode then.
All in all, I'd send the main outs stereo to FOH and use the Crown/Mesa in mono via monitor outout (Cabs off). You'll want to use the Crowne's bridged mono mode then.
Would I use a TRS cable for the monitor out connection?
Also, wouldn't running the amp in bridged mono @ 600w overpower the 240w cab?
Would I use a TRS cable for the monitor out connection?
Also, wouldn't running the amp in bridged mono @ 600w overpower the 240w cab?
You need a TS cable.
It's unlikey you overpower the 240W cab if you're a bit careful not to turn everything fully up.
Display More-Mesa Boogie 4x12 cab: MESA Engineering 4 x 12 Rectifier Standard Slant Guitar Cabinet
-Crown XLS202D power amp: Crown XLS-202D Power Amplifier 200W @ 8 Ohms | PSSL
Is this a compatible rig? If not, please elaborate.
Also, would a QSC HPR152i be a better fit? QSCHPR152I
Thanks!
The Crown/Mesa combination will work, but that cabinet will color all rigs. You loose the ability to sound exactly like the amps from other manufacturers. You will also struggle to achieve the similar sound on stage as through FOH unless you use a microphone in front of the mesa-cab to feed the FOH-system.
The QSC speaker is a more versatile option for the KPA, but I would recommend a 12" cabinet instead of 15" for a guitar-system.
Yeah, but I think the OP knows this.. 
