Not sure if this will ever be possible, but something I thought would be extremely cool is if the profiler could profile isolated tracks. For example, there are oodles (yes, oodles) of Duane Allman, Jimmy Page, Eric Clapton, George Harrison, etc., isolated tracks (where the lead guitar has been separated from the rest of the mix) floating around, and it would be awesome if those tracks could be profiled... so instead of profiling an amp, you would be profiling an artist using a particular amp.
Again, probably not in the cards, but a cool thought nonetheless.