You have to remember that a single guitar is going to sound pretty thin outside of a mix. You can add more low end EQ to the tone but that usually gets cut anyway in a mix. A bass track really fills out and thickens the guitar tone. Studio Monitors are better suited for mixing tracks and not for a stand-alone guitar sound until after your ears get accustomed to them.
I would look up some iso tracks of your favorite guitarist and tones and then pay particular attention to how they sound with your monitors. Don't just listen but really study how they sound and then base your profile tweaks on that.
I'm learning this stuff as I go, too!