Hi,
This may have been posted before so if that's the case I apologize!
Sometimes I find the bridge single coil pickup on a strat to be a bit weak and anemic for lead sounds. Clean and distorted!
Put the Lead booster in front of the amp profile, set the volume somewhere between o and 1 and the use the tone control in the Lead Booster to find the spot that fits your guitar the best. I find this not only varies from guitar to guitar but also from profile to profile.
I use this quite a lot.
Cheers,
Mats N