Explored the INPUT options. I dropped the Distortion Sense a little bit to -2.2 db. Ive gone thru about 50 rigs and the Strat sounds good. No other modifications have been made. This seems like a good omen.
Yes, Input sense is very important. You have to set it right for every guitar, to get the best sound. The strength of signal from guitar differs a lot. It depends on strings material, pickup construction, pickup height.... This is what I wanted to suggest you to tweak.
BTW, you can save different setups of input sense as presets for different guitars you have. When you change guitar, all you have to do is switch input preset.