This is currently the last thing i'm battling with to be 100% happy with my live sound
I'm finding that for any profile, to play at gig volume levels i have to have quite extreme noise gate settings in order to avoid feedback. These settings mean a reduction in tone and actually make playing some parts quite difficult.
Currently i'm using a 2:1 gate first in the stomp chain (nothing else in chain) with a threshold of 7.6. Would prefer to avoid the global gate as i don't want my clean profiles affected.
NOTE: I'm aware this isn't strictly a KPA issue. Any high gain solution requires gating, i'm just interested to find out what other users are doing.