To all of you: great suggestions!! .
I notice however that some go from a single coil strat or tele. I've found the TD-Jimi Hendrix-2020-11-11 12-35-02 krig in that Tribute Collection 1 and tried this one first with my Les Paul with incl. that Octa Shaper + Phaser Vibe...Rolled treble down and the result is quite amazing!! Il'l tweak a bit more but it's a great rig now!
Don: I allready tried that Tone pot down but the result was not spectacular. Maybe due to my Les Paul humbuckers?
Anyway, to all of you: Thank you so much!
So the song if I'm not mistaken is Red Hot Chili peppers and John Fruscanti has a very Hendrix sound in general. This comes from his Strat as a starting point and unsurprisingly he goes into a Marshall. According to Google he uses a Boss turbo distortion and Big Muff.
So the sound to me is his Marshall on the edge of breakup, big Muff to give a big of old school fizz, with his neck pickup or position 4 on his strat. I would use a cleanish marhsall sound with a bit of Kemper fuzz, but you need that start neck pickup element.
I think you have raised a similar thing before where you are trying to get a single coil sound from your Les Paul.
If this is a common problem for you, either get a start as a second guitar or I would suggest getting a humbucker with a split coil and using a push pull pot to keep things tidy. Whilst this will never sound the same as a Strat, it will get you a bit closer and should not be too expensive.