I've found that almost all profiles worked best with one type of guitar och one kind of pickup. M Britt's Dumbles works well with Gibson scale guitars with humbuckers but so far I can't get them to work with single coils. Many other profiles (like the Golub Crunch) only work with single coils.
But Andy's Evil Robot profiles works with every guitar I have. Construction and pickup selection doesn't matter. It just works and it's very dynamic. Works especially well with my right hand dynamically controlling OD.