I used to have a desire to buy drive pedals, and still use a couple in the loop. The Profiler can get close - but it can't totally nail the King of Tone. There is a harmonic 'richness' I've never been able to dial in that's just 'there' with the actual pedal. Having waited four years to get it.....I'll accept no substitute.
Since I'm already using a slot for the effects loop.....and I like to tinker and build stuff..... I've got a 3 loop MIDI switcher. So....both sides of the KOT and whatever pedal feels right at the time. Presently, that's a Tumnus Deluxe. That gives me the chance to stack as many as three drives with only one slot used.
Try diff cables. i really find the difference can be 5 percent here or there. An sometimes its that 5 percent thats missing.