I have about 8 performances, each based upon a different amp, so for example, an AC30 performance, a Fuchs, a Bassman etc. Each performance has 4 or 5 difference profiles of the same amp going from clean on the left, to crunchy on the right.
I have the same stomp set up for each amp, including compressor, Green Scream, studio eq, ad chorus, with a solo boost in X and tremolo in the MOD slot. I have duplicate performances with a different effect in slot D, so if I ever need a wah for example, I just go to that performance.
I have two "pedal boards" that I use. One is a chopped FCB1010 and the other is a 4 button FS, and I use either depending on the circumstances of the gig.
In this way, I can play around with different amps in a gig. We play a mix of rockin' blues, jazz and a bit of surf, so I can cover it all.
I've played about 10 gigs like this and it works out ok, although I have to admit, managing the volume/gain impact of switching different fx is driving me a bit mad.