For those of us that aren't commercial profilers, we usually have to rely on the ears of the guys doing the profiles to get it right. In that sense, I really appreciate it when profilers post takes of the same amplifier with different settings. Perhaps it would make as much sense to break those multiple mic setups into individual profiles and leave it to the user to blend it, something like the recent Ace of Skunk Anansie profiles that were posted, i.e. stuff that works well together.
That would be my idea for recording, but for live? I want to capture as many of the characteristics of the original amplifier as possible. In that sense, multiple micing might be the only way to capture the whole spectrum of tone from an amplifier, though again, the results would be coloured by placement, EQing, etc. Then again, I don't have the amplifier and have no idea how it sounds: it is in my best interests to use the profiles created by guys that can say, "This is the authentic sound of the amplifier".
If the end justifies the mean, I'm not going to nitpick and say, "Only this works" or "Only that works". Perhaps the one thing that could be drawn from this thread for commercial profilers is that we want more flavours, which gives us a better say in how the guitar parts sit in the mix, rather than having to complicate things by modifying a sound to suit the mix, or being forced to base our entire mix on that sound. Means more work, but it also means more satisfied customers.