There is a simple rule here in Texas. You pick no more than 3 tones; clean, crunch, high-gain/solo. You play those all night to your heart's delight. I have never been to a small gig or mega concert where I heard more than 3 tones. The more famous had only 1 tone/amp the whole show.
What I meant in my previous post is that it's possible to have just the same amp profile throughout the entire performance with different effects or settings on each individual slot. If you are a steady member of an original band that always play the same repertoire of 10-20 songs over and over in concerts or festivals, it's worth investing time in programming 1 performance/song instead of tap dancing to trigger effects on and off of every rig etc. Anyway, feel free to find out what works best for yourself but I'm saying this with a long history of both disasters happening by mismanaging rigs and smooth sessions with perfect sounds just at the click of a switch. 5 slots/song doesn't necessarily mean "too many sounds" nor is "overkill"; it could be the same exact sound with just a slight volume difference - having it in a different slot can sometimes make management more straightforward and less confusing.