When you use 3rd-party profiles there is no guarantee that the settings that were dialled in on the amp prior to profiling would work well with all your guitar. For the most consistent results you should perform a comparison using a real amp that you like and a profile of that amp.
- Dial in a tube amp with a setting that you find give reasonable results with all guitars (no reverb or other fx). The tonal spectrum of different pickups vary so much I find this to be near impossible, but by all means give it a go.
- Create a profile of this amp/settings
- Record clips with all the different guitars through the amp and through the sampled profile. Don't touch a knob on either the amp or the profiler while recording.
- Post the resulting clips here and also submit them to Kemper support to get an analysis of the differences you experience