For many years i've always had simple setup- guitar into amp, maybe a touch of rev/del then out the other end, even owning multi-effects processors and the good-old 'marshall JMP1' i had prior to the KPA.
For boost/solo stuff with the Kemper (the same as my old setup) it was a case of finding a similar or same profile/settings with more gain and knock the output level up a few dB.
Seems to me that many players rely on a stomp and can be quite particular about their favourite overdrive pedals in front of their amp (KPA=pre-amp stomp slots) for that extra drive or maybe just to dirty up their tone. I've often found this to colour the sound going in to the amp in a non-favourable way, but thats just my "old school" approach.
So, i'd be interested to hear how everyone else uses their overdrive/distortion FX in stomps 1-4 (pre-amp) and their reasons and chosen FX/settings. I might be missing something good here having been a minimalist for well over 2 decades. perhaps someone will show me otherwise...?